![]() ![]() He nurtured my enthusiasm for synthetic organic chemistry, as well as for NMR (nuclear magnetic resonance, author’s note), which enriched my knowledge a lot and ended up also guiding my subsequent career path. During my undergraduate years, I was influenced greatly by another Experientia stipend award holder from 2018, Lukáš Maier, who at that time worked at Masaryk University as a doctoral student in Assoc. Thanks to her I found chemistry very interesting and decided to study it at university. The decisive factor for me was having a great chemistry teacher, Mrs Smreková. When I was at grammar school, I enjoyed all kinds of subjects – political science, psychology, medicine I was even thinking about studying journalism. If you look at your career path up to this point, what do you think was the most important thing that has led to this moment? What were the most formative experiences?Īctually, I’m not from a family of chemists. ![]() In addition, I’m also really looking forward to being a member of the new group, to new projects and topics, to creative challenges… It will be a huge boost for my career and a wonderful opportunity to move forward, work on my own research ideas, try another area of synthetic organic chemistry, and expand my knowledge of chemical biology. What they have done for Czech science by supporting young scientists in their dreams of an internship abroad and also of running their own research groups is just extraordinary. The Dvořáks, the founders of the Experientia Foundation, are a unique example of good will and modesty, and it means a lot to me that they have decided to support my project. I’m extremely thrilled! The University of Cambridge is a dream come true that would most likely have remained just a fantasy without the fellowship. Thanks to your stipend from the Experientia Foundation, from July you will be a researcher at the renowned University of Cambridge. With peptide compounds formed in this way, we could for example deliver a drug to a specific target in the body and release it there,” Soňa explains. We want to develop a methodology for so-called multifunctional staples, which will enable us to prepare various biologically interesting stapled peptides. “To date, peptide stapling has only been used to incorporate a single substance into a peptide. As a new Experientia Foundation stipend award holder, Soňa Krajčovičová is planning to take the development of the peptide-stapling method further during her one-year research stay at the University of Cambridge as a member of Professor David R. The staples enhance the peptide’s resistance to enzymatic cleavage and can also be used to introduce other compounds, thus expanding their potential as biologically useful substances. One such method is “stapling”, which allows the peptide structure to be “locked” in a more stable spatial arrangement using the peptide’s side chains. Scientists are therefore looking for novel ways of improving peptide properties to make them last longer in the body. One of the limitations of linear peptides is their instability in the physiological environment, where they can be enzymatically cleaved. ![]() They make up proteins, including enzymes, hormones, and antibodies. Peptides – chains of amino acids linked by amide bonds – play an indispensable role in the human body.
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